Impact of timing of adjuvant radiotherapy on locoregional control in patients with high-risk endometrial cancer

Aim: High-risk endometrial cancer has a higher risk of regional and distant recurrence. We sought to examine our institutional experience regarding the timing adjuvant radiotherapy local failure (LF), locoregional (LRF), (DF), overall survival (OS). Methods: retrospectively reviewed database patients with high-risk treated sequential chemotherapy followed by external beam radiation therapy (EBRT) or without brachytherapy from 2012 2019. Results: One hundred thirty-one were identified. The median age at diagnosis was 65 (range 32-81). most prevalent FIGO stages IIIB (28.2%, n = 37), IIIC1 (19.8%, 26), IIIA (17.6%, 23). Of patients, 29% (n 38) had positive lymph nodes 71% 93) negative nodes. histology endometrioid (71%, 93), serous (12.2%, 16), clear cell (9.2%, 12), other (7.6%, 10). Moreover, 100% 131) completed EBRT. mean EBRT dose 49.6 Gy 45-50.4). number days between surgery 212.4 103-219). 14.7 12-30). cumulative incidence LF 6.1%, LRF 19%, DF 33.4 months. For who 180 after surgery, (HR 3.55 [1.23-10.2], P 0.013), 1.91 [0.4-8.9], 0.429), 0.91 [0.41-2], 0.806), OS 0.92 [0.33-2.6], 0.87). Conclusion: In cohort radiotherapy, delaying RT associated an increased but no differences in OS.